TY - JOUR AU - Ghochikyan, Tariel V. AU - Galstyan, Armen S. AU - Stepanyan, Hrachik M. AU - Korpakova, Irina G. AU - Kinzirsky, Alexander S. PY - 2021/08/30 Y2 - 2024/03/28 TI - STUDY OF THE BIOLOGICAL PROPERTIES OF SEMI- AND THIOSEMICARBAZONES OF CARBONYL DERIVATIVES OF 4-BUTANOLIDES JF - Proceedings of the YSU B: Chemical and Biological Sciences JA - Proc. YSU B: Chem. Biol. Sci. VL - 55 IS - 2 (255) SE - Chemistry DO - 10.46991/PYSU:B/2021.55.2.103 UR - https://journals.ysu.am/index.php/proceedings-chem-biol/article/view/vol55_no2_2021_pp103-111 SP - 103-111 AB - <p>Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga <em>Cladophora</em> and blue-green alga (cyanobacterium) <em>Synechocystis</em> and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia <em>P-388</em>, Lewis lung carcinoma, <em>B16 </em>melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemi­carbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․</p> ER -