ANTIBACTERIAL AND ANTI-PHAGE ACTIVITY OF $PLANTAGO$ $MAJOR$ L. RAW MATERIAL

Abstract

Plantago major L. is a popular medicinal herb, which has been being used for treatment of various diseases in traditional health systems. The aim of present study was to examine the antibacterial and anti-phage activity of P. major ethanol extract. P. major fresh raw material extract was possessed of moderate antibacterial activity against Escherichia coli VKPM-M17, Salmonella typhimurium TA 100 and Staphilococcus aureus MDC 5233 bacterial strains. Anti-phage activity was evaluated by double overlay plaque assay against T4 phage of E. coli C-T4. Fresh, dried and frozen raw materials showed moderate antiviral activity: 1 mg/mL concentration of fresh row material ethanol extract caused 0.927Log₁₀ reduction of phage units, while the frozen and dried plant ethanol extracts caused 0.875 Log₁₀ and 0.821 Log₁₀ reductions, respectively. Fresh raw material contains the highest concentration of vitamin C.