ALTERATION OF TOTAL AND MITOCHONDRIAL ATPASE ACTIVITY IN THE BREAST AND LIVER IN BREAST CANCER-INDUCED RATS

Authors

  • Seda V. Marutyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia
  • Gayane A. Petrosyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia
  • Anna R. Muradyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia
  • Lilit A. Marutyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia
  • Syuzan A. Marutyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia
  • Nikolay V. Avtandilyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2022.56.2.151

Keywords:

tumor, cancer, breast, liver, ATPase activity

Abstract

A preliminary evaluation of ATPase was performed in an experimental model of breast cancer. Total and mitochondrial ATPase activities were studied in the breast and liver of rats with DMBA-induced breast cancer. It has been shown that during the development of breast cancer in these tissues there is a significant increase in ATPase activity. At the same time, an increase in ATPase activity is seen in the liver of rats. In the case of treatment cancer rats with H.alpestre, there are almost no changes in ATPase activity in rats' liver homogenate and mitochondria compared to cancer animals. In the case of combined treatment with chemical inhibitors and H.alpestre, ATPase activity is significantly reduced with the use of L-NAME, the values obtained are lower even compared to healthy animals. However, with the use of nor-NOHA, a further increase in ATPase activity is observed. The obtained results will allow evaluation of the effectiveness of the therapeutic model by changing the energy balance, and selecting furthermore effective doses, to clarify the mechanisms of influence of these combination models.

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Published

2022-08-28

How to Cite

Marutyan, Seda V., Gayane A. Petrosyan, Anna R. Muradyan, Lilit A. Marutyan, Syuzan A. Marutyan, and Nikolay V. Avtandilyan. 2022. “ALTERATION OF TOTAL AND MITOCHONDRIAL ATPASE ACTIVITY IN THE BREAST AND LIVER IN BREAST CANCER-INDUCED RATS”. Proceedings of the YSU B: Chemical and Biological Sciences 56 (2 (258):151-60. https://doi.org/10.46991/PYSU:B/2022.56.2.151.

Issue

Section

Biology