STUDY OF THE ANTIHYPOXIC EFFICIENCY OF SUCCINATE UNDER THE CONDITIONS OF METHEMOGLOBINEMIA

Authors

  • Narine K. Hayrapetyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2022.56.3.245

Keywords:

methemoglobinemia, antihypoxic activity, succinic acid

Abstract

Modeling of methemoglobinemia (MetHb) led to a violation of antioxidant protection, which was manifested by a decrease in the activity of enzymes of the primary link of the antioxidant system – superoxide dismutase and catalase in blood plasma and brain homogenates of experimental animals. The state of MetHb also led to an increase in the concentration of malondialdehyde, an indicator of lipid peroxidation, as well as an indicator of oxidative modification of proteins. It has been established that the antihypoxic activity in the application of succinic acid significantly suppresses the biochemical changes caused by the hypoxic state.

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Published

2022-12-28

How to Cite

Hayrapetyan, Narine K. 2022. “STUDY OF THE ANTIHYPOXIC EFFICIENCY OF SUCCINATE UNDER THE CONDITIONS OF METHEMOGLOBINEMIA”. Proceedings of the YSU B: Chemical and Biological Sciences 56 (3 (259):245-52. https://doi.org/10.46991/PYSU:B/2022.56.3.245.

Issue

Vol. 56 No. 3 (259) (2022)

Section

Biology

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Copyright (c) 2022 Proceedings of the YSU

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