THE INTERACTION OF Ag-CONTAINING PORPHYRINS WITH DNA AT HIGH IONIC STRENGTH

S. A. A. Sulyman; A. A. Ghazaryan; Ye. B. Dalyan

doi:10.46991/PYSU:A/2009.43.2.055

THE INTERACTION OF Ag-CONTAINING PORPHYRINS WITH DNA AT HIGH IONIC STRENGTH

Authors

S. A. A. Sulyman Mosul University, Irak, Chair of the Molecular Physics, YSU, Armenia
A. A. Ghazaryan Chair of Molecular Physics, YSU, Armenia
Ye. B. Dalyan Chair of Molecular Physics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:A/2009.43.2.055

Keywords:

DNA, porphyrin, ionic strength

Abstract

UV-VIS spectrophotometry and circular dichroism (CD) methods were applied to study the binding of DNA with three novel Ag-containing porphyrins meso-tetra(4N-allylpyridyl) (AgTAlPyP4), meso-tetra(4N-butylpyridyl) (AgTButPyP4) and meso-tetra(4N-oxyethylpyridyl) (AgTOEtPyP4) at high ionic strength. The binding constant K_b and stoichiometry n were determined from binding isotherms for each ligand–DNA complex. The Gibbs free energy, enthalpy and entropy of binding also were calculated using the values of K_b . Obtained results show that these porphyrins associate with the duplex DNA via outside binding mode.

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Published

2009-06-26

How to Cite

Sulyman, S. A. A., Ghazaryan, A. A., & Dalyan, Y. B. (2009). THE INTERACTION OF Ag-CONTAINING PORPHYRINS WITH DNA AT HIGH IONIC STRENGTH. Proceedings of the YSU A: Physical and Mathematical Sciences, 43(2 (219), 55–59. https://doi.org/10.46991/PYSU:A/2009.43.2.055