DNA–LIGAND COMPLEXES MELTING: THE EFFECT OF MULTIPLE BINDING MECHANISMS

Z.A. Grigoryan

doi:10.46991/PYSU:A/2016.50.1.052

DNA–LIGAND COMPLEXES MELTING: THE EFFECT OF MULTIPLE BINDING MECHANISMS

Authors

Z.A. Grigoryan Chair of Physics YSUAC, Goris State University, Armenia

DOI:

https://doi.org/10.46991/PYSU:A/2016.50.1.052

Keywords:

helix–coil transition; biphasic denaturation; multiple binding

Abstract

Helix–coil transition of complexes DNA with two ligands of different binding mechanisms to native and melted regions of biopolymer is considered using the most probable distribution method. It was shown that obtained biphasic behavior of helix–coil transition curves depends on both binding affinity and concentration of ligands in solution. Thermodynamic behavior of the ligands having higher and lower affinity to the native DNA is compared.

Downloads

Published

2016-03-18

How to Cite

Grigoryan, Z. (2016). DNA–LIGAND COMPLEXES MELTING: THE EFFECT OF MULTIPLE BINDING MECHANISMS. Proceedings of the YSU A: Physical and Mathematical Sciences, 50(1 (239), 52–57. https://doi.org/10.46991/PYSU:A/2016.50.1.052