MEMBRANOTROPIC EFFECT OF MONTIVIPERA RADDEI AND MACROVIPERA LEBETINA OBTUSA VENOM WITH PHOSPHOLIPASE A2 INHIBITED BY p-BROMOPHENACYL BROMIDE

Authors

  • L.A. Ghulikyan Laboratory of Toxicology, L. A. Orbeli Institute of Physiology, NAS RA

DOI:

https://doi.org/10.46991/PYSUB.2015.49.3.047

Keywords:

GUV, $Macrovipera~lebetina~obtuse$, $Montivipera~raddei$,phospholipase A2, p-bromophenacyl bromide

Abstract

In the article influence of Montivipera raddei and Macrovipera lebetina obtusa venom including phospholipase A2 (PLA2) inhibited by p-bromophenacyl bromide on giant unilamellar vesicles, visualized with 8-anilino-1-naphthalenesulfonic acid fluorescence probe, was investigated. The results have shown that both venoms even without the PLA2 activity have a noticeable membranotropic effect on the artificial membranes, but in different ways, so one can propose that investigated viper venoms can contain different PLA2 isomers.

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Published

2015-11-20

Issue

Vol. 49 No. 3 (238) (2015)

Section

Biology

License

Copyright (c) 2015 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“MEMBRANOTROPIC EFFECT OF MONTIVIPERA RADDEI AND MACROVIPERA LEBETINA OBTUSA VENOM WITH PHOSPHOLIPASE A2 INHIBITED BY P-BROMOPHENACYL BROMIDE”. 2015. Proceedings of the YSU B: Chemical and Biological Sciences 49 (3 (238): 47-52. https://doi.org/10.46991/PYSUB.2015.49.3.047.

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