ALTERATIONS IN ARGINASE ACTIVITY, NITRIC OXIDE, AND MDA LEVELS IN BONE MARROW DURING DMBA-INDUCED BREAST CANCER IN RATS

Authors

  • Svetlana M. Hovhannisyan Laboratory of Basic and Pathological Biochemistry, Research Institute of Biology, YSU, Armenia
  • Aqsana S. Hakobyan Laboratory of Basic and Pathological Biochemistry, Research Institute of Biology, YSU, Armenia
  • Arpine N. Hakobyan Laboratory of Basic and Pathological Biochemistry, Research Institute of Biology, YSU, Armenia
  • Astghik A. Mkrtchyan Laboratory of Basic and Pathological Biochemistry, Research Institute of Biology, YSU, Armenia
  • Hayarpi G․ Javrushyan Laboratory of Basic and Pathological Biochemistry, Research Institute of Biology, YSU, Armenia https://orcid.org/0000-0002-6941-8283

DOI:

https://doi.org/10.46991/PYSUB.2025.59.3.113

Keywords:

breast cancer, bone marrow, malondialdehyde, 5-fluorouracil, L-NAME, nor-NOHA, 5-FU, arginase, nitric oxide

Abstract

This study investigates the therapeutic potential of herbal extracts to mitigate bone marrow damage during DMBA-induced breast cancer and its treatment in rats. Untreated tumor-bearing rats showed elevated arginase activity and malondialdehyde (MDA) levels with reduced nitric oxide (NO) bioavailability. Treatment with herbal extract combined with the arginase inhibitor nor-NOHA, significantly reduced MDA and restored NO levels, demonstrating antioxidant and protective effects on the bone marrow. Conversely, combining a NOS inhibitor (L-NAME) with herbal extract exacerbated oxidative damage. The findings support using specific phytotherapeutics as adjuvants to conventional cancer therapy to maintain bone marrow integrity.

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Published

2025-12-15

Issue

Vol. 59 No. 3 (267) (2025)

Section

Biology

License

Copyright (c) 2025 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“ALTERATIONS IN ARGINASE ACTIVITY, NITRIC OXIDE, AND MDA LEVELS IN BONE MARROW DURING DMBA-INDUCED BREAST CANCER IN RATS”. 2025. Proceedings of the YSU B: Chemical and Biological Sciences 59 (3 (267): 113-21. https://doi.org/10.46991/PYSUB.2025.59.3.113.

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