COMPARATIVE STUDY OF THE INTERACTION OF NEUROTRANSMITTERS DOPAMINE AND SEROTONIN WITH DNA
DOI:
https://doi.org/10.46991/PYSUB.2026.60.3.136Keywords:
dopamine, serotonin, UV-melting, absorption spectroscopy, fluorescence spectroscopyAbstract
Comparative study of the interaction of neurotransmitters dopamine and serotonin with DNA has been carried out, using the methods of ultraviolet melting, as well as absorption and fluorescence spectroscopies. The obtained results reveal that both ligands immediately bind to DNA, meanwhile serotonin stabilizes the double-stranded structure of the latter stronger, than dopamine. At the binding to DNA the similar fluorescence quenching of both neurotransmitters is observed. On the other hand, the absorption properties of the complexes dopamine–DNA and serotonin–DNA significantly differ: at the formation of dopamine complexes with DNA, hypochromic effect occurs, at the formation of serotonin – hyperchromic effect.
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