BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV
DOI:
https://doi.org/10.46991/PYSU:B/2013.47.1.036Keywords:
amyloid beta peptides, dipeptidyl peptidase IV, fibril formation, Proline Rich Peptide 4, enzymatic cleavage of Aβ peptidesAbstract
It is shown that the amyloid beta peptides Aβ(1-16) and Aβ(1-40) and a cytokine from neurosecretory granules of bovine neurohypophysis, Proline Rich Peptide PRP-4, are truncated at the presence of multifunctional dipeptidyl peptidase IV (CD26/DPPIV), widely expressed in different mammalian tissues. It means that these neuropeptides represent substrates of the enzyme. Besides, it appeared that at the presence of CD26/DPPIV the process of Aβ(1-40) aggregation in vitro was hindered.
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Published
2013-03-10
How to Cite
Movsisyan, N.M., S.G. Sharoyan, A.A. Antonyan, and S.S. Mardanyan. 2013. “BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV”. Proceedings of the YSU B: Chemical and Biological Sciences 47 (1 (230):36-39. https://doi.org/10.46991/PYSU:B/2013.47.1.036.
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Biology
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