ADENOSINE DEAMINASE ACTIVITY IN SYNOVIAL FLUID AT ARTHRITIS

Authors

  • A.A. Antonyan H.Ch. Buniatian Institute of Biochemistry of NAS of RA
  • S.G. Sharoyan H.Ch. Buniatian Institute of Biochemistry of NAS of RA
  • A.A. Haroyan YSMU after M. Heratsi, Armenia
  • R.A. Harutyunyan YSMU after M. Heratsi, Armenia
  • S.S. Mardanyan H.Ch. Buniatian Institute of Biochemistry of NAS RA

DOI:

https://doi.org/10.46991/PYSU:B/2013.47.3.028

Keywords:

adenosine deaminase, ADA-test, differentiation of arthritis, rheumatoid arthritis, osteoarthritis, synovial fluid

Abstract

It was found that the levels of Adenosine deaminase activity in joint effusions of patients with rheumatoid arthritis and osteoarthritis differ significantly (p < 0.0001). To differentiate the arthritis of these two etiologies, the cutoff value of the enzyme activity in synovial fluid was evaluated as 12 IU/L with sensitivity 0.96, specificity 0.89 and diagnosis efficiency 0.93. Based on this observation, we can offer using in clinics of Armenia the Adenosine deaminase activity in synovial fluid for quick diagnosis of rheumatoid arthritis as a sensitive, specific, low-cost and technically convenient test.

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Published

2013-11-15

How to Cite

Antonyan, A.A., S.G. Sharoyan, A.A. Haroyan, R.A. Harutyunyan, and S.S. Mardanyan. 2013. “ADENOSINE DEAMINASE ACTIVITY IN SYNOVIAL FLUID AT ARTHRITIS”. Proceedings of the YSU B: Chemical and Biological Sciences 47 (3 (232):28-32. https://doi.org/10.46991/PYSU:B/2013.47.3.028.

Issue

Vol. 47 No. 3 (232) (2013)

Section

Biology

License

Copyright (c) 2013 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.