ADENOSINE DEAMINASE ISOFORMS IN SYNOVIAL FLUID AT RHEUMATOID ARTHRITIS

Authors

  • A.A. Antonyan H.Ch. Buniatian Institute of Biochemistry, NAS RA
  • S.G. Sharoyan H.Ch. Buniatian Institute of Biochemistry, NAS RA
  • A.A. Haroyan Yerevan State Medical University after M. Heratsi, Armenia
  • R.H. Harutyunyan Yerevan State Medical University after M. Heratsi, Armenia
  • S.S. Mardanyan H.Ch. Buniatian Institute of Biochemistry, NAS RA

DOI:

https://doi.org/10.46991/PYSU:B/2014.48.2.054

Keywords:

adenosine deaminase isoforms, inflammatory arthritis, synovial fluid

Abstract

The level of adenosine deaminase (ADA) activity in synovial fluids of patients with inflammatory arthritis (IA) and non-inflammatory joint diseases differ significantly. In this work from synovial fluids with different levels of the ADA activity, low- and high-molecular isoforms were separated. The increasing of low-/high- molecular ratio upon increasing the total ADA activity was manifested. It was supposed that the increase of total ADA activity at inflammation takes place, because of the release of intracellular, low-molecular ADA. To prevent the anti-inflammatory agent, adenosine, against metabolizing by the enzyme, its inhibition might be considered as a new approach to the IA treatment.

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Published

2014-07-01

How to Cite

Antonyan, A.A., S.G. Sharoyan, A.A. Haroyan, R.H. Harutyunyan, and S.S. Mardanyan. 2014. “ADENOSINE DEAMINASE ISOFORMS IN SYNOVIAL FLUID AT RHEUMATOID ARTHRITIS”. Proceedings of the YSU B: Chemical and Biological Sciences 48 (2 (234):54-57. https://doi.org/10.46991/PYSU:B/2014.48.2.054.

Issue

Vol. 48 No. 2 (234) (2014)

Section

Biology

License

Copyright (c) 2014 Proceedings of the YSU

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