PLANT PREPARATIONS SUPPRESS THE AGGREGATION OF AMYLOID BETA PEPTIDES AND PROMOTE THEIR DISAGGREGATION

Authors

  • S.G. Sharoyan H.Ch. Buniatian Institute of Biochemistry, NAS RA
  • A.A. Antonyan H.Ch. Buniatian Institute of Biochemistry, NAS RA
  • H.A. Harutyunyan H.Ch. Buniatyan Institute of Biochemistry, NAS RA, Yerevan State Medical University after M. Heratsi, Armenia
  • S.S. Mardanyan H.Ch. Buniatian Institute of Biochemistry, NAS RA

DOI:

https://doi.org/10.46991/PYSU:B/2015.49.3.039

Keywords:

Aβ (1-40) and Aβ (1-42) peptides, aggregation, disaggregation, plant extracts, plant constituents

Abstract

Fibrillation of amyloid Aβ (1-42) and Aβ (1-40) peptides (Aβs) is considered as one of causes of Alzheimer’s disease. In the present work we studied the influence of some plant preparations on the aggregation state of these peptides, evaluated by fluorescence of thioflavin T-containing samples. The abilities of some preparations to inhibit the self-aggregation of Aβs and to disaggregate their preformed aggregates were demonstrated. For somecases, IC50 values in these processes were evaluated. Based on the obtained data we recommend: a) frequent use of these plants by persons at risk group; b) clinical evaluating their extracts as sources of neurodegeneration preventing agents.

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Published

2015-11-20

How to Cite

Sharoyan, S.G., A.A. Antonyan, H.A. Harutyunyan, and S.S. Mardanyan. 2015. “PLANT PREPARATIONS SUPPRESS THE AGGREGATION OF AMYLOID BETA PEPTIDES AND PROMOTE THEIR DISAGGREGATION”. Proceedings of the YSU B: Chemical and Biological Sciences 49 (3 (238):39-46. https://doi.org/10.46991/PYSU:B/2015.49.3.039.

Issue

Vol. 49 No. 3 (238) (2015)

Section

Biology

License

Copyright (c) 2015 Proceedings of the YSU

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