THE EFFECT OF NORMOBARIC AND HYPOBARIC HYPOXIA ON THE ELECTRICAL ACTIVITY OF THE BRAIN AND CARDIORESPIRATORY RESPONSE

Authors

  • Marietta A. Karapetyan Laboratory of Human and Animal Integrative and Adaptive Physiology, Research Institute of Biology, YSU, Yerevan, Armenia
  • Nona Yu. Adamyan Chair of Human and Animal Morphology and Physiology, YSU, Yerevan, Armenia
  • Emma S. Gevorgyan Chair of Human and Animal Morphology and Physiology, YSU, Yerevan, Armenia https://orcid.org/0009-0003-3967-7406

DOI:

https://doi.org/10.46991/PYSUB.2026.60.3.158

Keywords:

hypobaric and normobaric hypoxia, neuronal activity, cerebral cortex, heart and respiration rate

Abstract

The subject of study is the comparative assessment of electrical activity of the brain and cardiorespiratory response during normobaric and hypobaric hypoxia. For the normal functioning of the mechanisms for maintaining the body's energy balance, it is necessary to preserve the parameters that characterize the functional abilities of oxygen transport systems. The experimental results show that atmospheric pressure is not the main factor influencing the electrical activity of brain cells and the autonomic functions of the body. It turns out that in both hypobaric and normobaric hypoxia, the cause of the observed changes in indicators is a decrease in the partial pressure of oxygen (PO2) in the environment, which leads to a decrease in oxygen tension in the blood (PaO2).

Downloads

Download data is not yet available.

References

Agadzhanyan N.A., Chizhov A.Ya. Classification of Hypoxic Conditions. Moscow, Kruk Publishing House (1988), 20 (in Russian).

Millet G.P., Faiss R., Pialoux V. Point: Hypobaric Hypoxia Induces Different Responses from Normobaric Hypoxia. J. Appl. Physiol. 112 (2012), 1783–1784. https://doi.org/10.1152/japplphysiol.00067.2012

Millet G.P., Debevec T. CrossTalk Proposal: Barometric Pressure, Independent of PO2, is the Forgotten Parameter in Altitude Physiology and Mountain Medicine. J. Physiol. 598 (2020), 893–896. https://doi.org/10.1113/JP278673

Mounier R., Brugniaux J.V. Counterpoint: Hypobaric Hypoxia does not Induce Different Responses from Normobaric Hypoxia. J. Appl. Physiol. 112 (2012), 1784–1786. https://doi.org/10.1152/japplphysiol.00067.2012

Richalet J. CrossTalk Opposing View: Barometric Pressure, Independent of PO2, is not the Forgotten Parameter in Altitude Physiology and Mountain Medicine. J. Physiol. 598 (2020), 897–899. https://doi.org/10.1113/JP279160

Angeli C.N., Shute R.J., Slivka D.R. Higher Muscle Tissue Oxygenation when Exposed to Hypobaric Hypoxia than Normobaric Hypoxia. J. Hum. Perf. Extrem. Environ 15 (2019). https://doi.org/10.7771/2327-2937.1117

Basualto-Alarcón C., Rodas G., et al. Cardiorespiratory Parameters during Submaximal Exercise under Acute Exposure to Normobaric and Hypobaric Hypoxia. Apunts. Med. de L'esport 47 (2012), 65–72. https://doi.org/10.1016/j.apunts.2011.11.005

Beidleman B.A., Fulco C.S., et al. Cycling Performance Decrement is Greater in Hypobaric Versus Normobaric Hypoxia. Extrem. Physiol. Med. 3 (2014), 1–9. https://doi.org/10.1186/2046-7648-3-8

Faiss R., Pialoux V., et al. Ventilation, Oxidative Stress, and Nitric Oxide in Hypobaric Versus Normobaric Hypoxia. Med. Sci. Sports Exerc. 45 (2013), 253–260. https://doi.org/10.1249/MSS.0b013e31826d5aa2

Loeppky J.A., et al. Ventilation during Simulated Altitude, Normobaric Hypoxia and Normoxichypobaria. Respir. Physiol. 107 (1997), 231–239. https://doi.org/10.1016/s0034-5687(97)02523-1

Ross C.I., Shute R.J., et al. Skeletal Muscle mRNA Response to Hypobaric and Normobaric Hypoxia after Normoxic Endurance Exercise. High Alt. Med. Biol. 20 (2019), 141–149. https://doi.org/10.1089/ham.2018.0147

Ando S., Komiyama T., et al. The Interactive Effects of Acute Exercise and Hypoxia on Cognitive Performance: A Narrative Review. Scandinavian Journal of Medicine & Science in Sports 30 (2020), 384–398. https://doi.org/10.1111/sms.13573

Rosales A.M., Shute R.J., et al. Independent Effects of Acute Normobaric Hypoxia and Hypobaric Hypoxia on Human Physiology. Sci. Rep. 12 (2022), 19570. https://doi.org/10.1038/s41598-022-23698-5

AkopyanN.S. Electrophysiological Study of Brain Activity during Hypoxia. Yerevan (1987) (in Russian).

Breslav I.S., Glebovsky V.D. Regulation of Breathing. Leningrad, Nauka (1981) (in Russian).

Sergeev O.S. Reaction of Rat Respiratory Neurons to a Hypoxic Stimulus: Physiol. Magazine Them. Sechenov. 81 (1995), 48–55.

Tarakanov I.A., Safonov V.A. GABAergic System and its Importance for the Regulation of Respiration: Human physiology 24 (1998),116–128 (in Russian).

Safonov V.A. Man in the Ocean of Air. Moscow (2006), 215 (in Russian).

Downloads

Published

2026-11-12

Issue

Vol. 60 No. 3 (270) (2026): In process

Section

Biology

License

Copyright (c) 2026 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“THE EFFECT OF NORMOBARIC AND HYPOBARIC HYPOXIA ON THE ELECTRICAL ACTIVITY OF THE BRAIN AND CARDIORESPIRATORY RESPONSE”. 2026. Proceedings of the YSU B: Chemical and Biological Sciences 60 (3 (270): 158-65. https://doi.org/10.46991/PYSUB.2026.60.3.158.

Most read articles by the same author(s)