THE COMET ASSAY APPLICATION FOR ESTIMATION OF DNA DAMAGE AND REPAIR. 2. SPONTANEOUS AND UV-INDUCED DNA DAMAGE IN GROUPS OF GENETIC RISK

Authors

  • G. G. Hovhannissian Chair of Genetics and Cytology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSUB.2003.37.3.146

Keywords:

periodic disease, UV-induced DNA damage, comet assay, repair processes

Abstract

The analysis of UV-induced DNA damage permits to reveal the comparative sensitivity of cells towards different DNA damaging agents. The comet assay has been used to estimate spontaneous and UV-induced DNA breaks in cells of two groups of genetic risk. In cells of patients with periodic disease and Chernobyl accident clean-up workers the statistically significant increase of UV-induced levels of DNA damage compared with healthy subjects has been revealed. But the level of spontaneous DNA damage in both groups does not differ from the control one. The role of repair processes in revealed effects is discussed.

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Published

2003-10-09

Issue

Vol. 37 No. 3 (202) (2003)

Section

Short Communications

License

Copyright (c) 2003 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“THE COMET ASSAY APPLICATION FOR ESTIMATION OF DNA DAMAGE AND REPAIR. 2. SPONTANEOUS AND UV-INDUCED DNA DAMAGE IN GROUPS OF GENETIC RISK”. 2003. Proceedings of the YSU B: Chemical and Biological Sciences 37 (3 (202): 146-49. https://doi.org/10.46991/PYSUB.2003.37.3.146.