ASYMMETRIC SYNTHESIS OF (S)-VINYLGLYCINE VIA CHIRAL Ni(II) COMPLEX SCHIFF’S BASE OF DEHYDROAMINOBUTANOIC ACID WITH (S)-N-(2-BENZOYLPHENYL)-1-(3,4-DICHLOR-BENZYL)PYRROLYDIN-2-CARBOXAMIDE

Authors

  • H. H. Hambardzumyan Chair of Pharmaceutical Chemistry, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2004.38.3.085

Keywords:

asymmetric synthesis of (S)-vinylglycine, nucleophile, Schiffs base, (S)-vinylglycine

Abstract

A new method for asymmetric synthesis of (S)-vinylglycine via nucleophile addition of benzylamine to C=C bond of dehydroaminobutanoic acid in Ni(ll) complex of Schiffs base with a chiral auxiliare (S)-N-(2-benzoylphenyI)-l-(3,4- dichlorbenzyl)pyrrolydin-2-carboxamide has been elaborated. After decomposition of the reaction mixture amino acid (S)-vinylglycine has been isolated with ee 48%.

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Published

2004-10-19

How to Cite

Hambardzumyan, H. H. 2004. “ASYMMETRIC SYNTHESIS OF (S)-VINYLGLYCINE VIA CHIRAL Ni(II) COMPLEX SCHIFF’S BASE OF DEHYDROAMINOBUTANOIC ACID WITH (S)-N-(2-BENZOYLPHENYL)-1-(3,4-DICHLOR-BENZYL)PYRROLYDIN-2-CARBOXAMIDE”. Proceedings of the YSU B: Chemical and Biological Sciences 38 (3 (205):085-090. https://doi.org/10.46991/PYSU:B/2004.38.3.085.

Issue

Vol. 38 No. 3 (205) (2004)

Section

Chemistry

License

Copyright (c) 2004 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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