SCREENING INVESTIGATION OF SOME NUMERICAL ABERRATIONS AT PATIENTS WITH ACUTE MYELOID LEUKEMIA BY FISH METHOD IN INTERPHASE CELLS

Authors

  • A. S. Mkrtchyan Chair of Genetics and Cytology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2005.39.2.084

Keywords:

myeloid leukemia, chromosomes 8, 10, 11, 7, X and Y, numerical aberrations, near-tetraploidy

Abstract

Numerical aberrations of 19 patients with acute myeloid leukemia have been studied by the technique of Fluorescence in situ hybridization (FISH) in interphase cells. The centromere specific DNA probes for chromosomes 8, 10, 11, 7, X and Y were prepared in the Department of Genetics and Cytology of YSU. We revealed different numerical aberrations of tested chromosomes (not less than 3%) at 10 patients. Near-tetraploidy was found at one of them. FISH method in interphase cells allowed to reveal cytogenetic abnormalities at patients with AML, as the conventional cytogenetic analysis is inaccessible, and screening application is recommended by us.

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Published

2005-06-10

How to Cite

Mkrtchyan, A. S. 2005. “SCREENING INVESTIGATION OF SOME NUMERICAL ABERRATIONS AT PATIENTS WITH ACUTE MYELOID LEUKEMIA BY FISH METHOD IN INTERPHASE CELLS”. Proceedings of the YSU B: Chemical and Biological Sciences 39 (2 (207):84-89. https://doi.org/10.46991/PYSU:B/2005.39.2.084.

Issue

Vol. 39 No. 2 (207) (2005)

Section

Biology

License

Copyright (c) 2005 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.