CHANGES OF TERTIARY STRUCTURE OF DNA AT INTERACTION WITH CIS-PLATINUM

Authors

  • T. S. Haroutiounian Chair of Biophysics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2006.40.1.148

Keywords:

cis-diamminedichloroplatinum(ll), UV-spectroscopic helix-coil transition method, high-molecular DNA

Abstract

The antitumour drug cis-diamminedichloroplatinum(ll) (cis-DDP) form covalent adduct with DNA both in vivo and in vitro. In the present work, UV-spectroscopic helix-coil transition method is used to analyze the changes of the high-molecular DNA double helix occur due to formation of complexes with cis-DDP at the concentration of cis-DDP 3·10-5<rb<3·10-3, where rb=Ccis-DDP/Cbound nucl..

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Published

2006-03-07

How to Cite

Haroutiounian, T. S. 2006. “CHANGES OF TERTIARY STRUCTURE OF DNA AT INTERACTION WITH CIS-PLATINUM”. Proceedings of the YSU B: Chemical and Biological Sciences 40 (1 (209):148-50. https://doi.org/10.46991/PYSU:B/2006.40.1.148.

Issue

Vol. 40 No. 1 (209) (2006)

Section

Short Communications

License

Copyright (c) 2006 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.