METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION AND HOMOCYSTEINE LEVEL AT ISCHEMIC STROKE

Authors

  • A. A. Hovsepyan Center for Medical Genetics NAS RA, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2006.40.1.151

Keywords:

homocysteine level in blood, ischemic stroke, heterozygous and homozygous mutation, gene C677T mutation

Abstract

Elevated homocysteine level in blood is known as independent risk factor for ischemic stroke. One of the most common causes of hyperhomocysteinaemia is methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation. 43 patients with last month ischemic stroke incident were investigated and compared with 39 healthy (controls). Total plasma homocysteine levels was significantly high in cases versus controls (18.94±1.49 and 9.77±0.86 (μmol/L), p<0.001). Mutations frequency concurs with available investigations results. Tendency of homocysteine level elevation connected with heterozygous and homozygous mutation of MTHFR gene was found.

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Published

2006-03-07

How to Cite

Hovsepyan, A. A. 2006. “METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION AND HOMOCYSTEINE LEVEL AT ISCHEMIC STROKE”. Proceedings of the YSU B: Chemical and Biological Sciences 40 (1 (209):151-53. https://doi.org/10.46991/PYSU:B/2006.40.1.151.

Issue

Vol. 40 No. 1 (209) (2006)

Section

Short Communications

License

Copyright (c) 2006 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.