HIGH SELECTIVE ASYMMETRIC SYNTHESIS OF (S)-β-(N-IZOPROPYLAMINO)-α-ALANINE

Authors

  • A. S. Bagdasaryan Chair of Pharmaceutical chemistry, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSUB.2009.43.2.032

Keywords:

izopropylamine, Schiff`s base, (S)-N-(2-benzoilphenyl)-1-(2-chlorbenzyl)pyrrolidine-2-carboxamide, (S)-β-N-izopropylaminoalanine

Abstract

Asymmetric addition of izopropylamine to C=C bond of NiII-complex Schiff`s base of dehydroalanine with modified chiral auxiliary (S)-N-(2-benzoilphenyl)-1-(2-chlorbenzyl)pyrrolidine-2-carboxamide was investigated and high selective method of asymmetric synthesis of non-protein amino acid (S)-β-N-izopropylaminoalanine (ee >97%) was developed.

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Published

2009-05-22

Issue

Vol. 43 No. 2 (219) (2009)

Section

Chemistry

License

Copyright (c) 2009 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“HIGH SELECTIVE ASYMMETRIC SYNTHESIS OF (S)-β-(N-IZOPROPYLAMINO)-α-ALANINE”. 2009. Proceedings of the YSU B: Chemical and Biological Sciences 43 (2 (219): 32-37. https://doi.org/10.46991/PYSUB.2009.43.2.032.