THE ENANTIOSELECTIVE SYNTHESIS OF NEW ANTY-(S)-β-OXY-SUBSTITUTED TYROSINES

Authors

  • A.S. Saghiyan Chair of Pharmaceutical Chemistry and Pharmacognosy, YSU, Armenia
  • A.S. Dadayan Chair of Pharmaceutical Chemistry and Pharmacognosy, YSU, Armenia
  • S.A. Dadayan Chair of Pharmaceutical Chemistry and Pharmacognosy, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSUB.2011.45.1.014

Keywords:

symmetric aldol condensation, Shiff base, glycine, tyrozine

Abstract

Reactions of asymmetric aldol condensation of Nill complex of the Shiff base of glycine and chiral auxiliary (S)-2-N-[N’-(2-fluorobenzylprolyl)amino]benzophe-none Nill-(S)-2-FBPB-Gly by benzaldehydes 4-CH3O-C6H4CHO, 3-Br-4-CH3O-C6H3CHO were investigated. As a results the synthesis of new enantiomericaly pure phenyl substituted derivatives of Tyrozine (2S, 3S)-β-oxy-4-OMe-Tyr (ee 91%) and (2S, 3S)-β-oxy-3-Br-Tyr (ee 92%) is carried out.

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Published

2011-02-02

Issue

Vol. 45 No. 1 (224) (2011)

Section

Chemistry

License

Copyright (c) 2011 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“THE ENANTIOSELECTIVE SYNTHESIS OF NEW ANTY-(S)-β-OXY-SUBSTITUTED TYROSINES”. 2011. Proceedings of the YSU B: Chemical and Biological Sciences 45 (1 (224): 14-19. https://doi.org/10.46991/PYSUB.2011.45.1.014.