ASSESSMENT OF GENOTOXIC PROPERTIES OF PROLINE-ENRICHED POLYPEPTIDE $in~vivo$ BY COMET ASSAY

Authors

  • D.N. Haroutounyan Chair of Genetics and Cytology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2011.45.2.060

Keywords:

genotoxicity, Comet assay, test-system, mice leucocytes, level of damage in DNA

Abstract

The genotoxicity of proline enriched polypeptide (PRP-1) was estimated in mice leucocytes depending on its action time in vivo by Comet assay. A high level of DNA damages compared with the control variants was revealed. As well as a small amount of DNA damage is revealed in comparison with the control and there is a tendency for decreasing the level of damage in DNA with the lapse of time after the introduction of PRP-1. Taking into consideration the low genotoxicity of PRP-1, we can conclude the safety of this drug demonstrated in the applied test-system.

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Published

2011-05-11

How to Cite

Haroutounyan, D.N. 2011. “ASSESSMENT OF GENOTOXIC PROPERTIES OF PROLINE-ENRICHED POLYPEPTIDE $in~vivo$ BY COMET ASSAY”. Proceedings of the YSU B: Chemical and Biological Sciences 45 (2 (225):60-63. https://doi.org/10.46991/PYSU:B/2011.45.2.060.

Issue

Vol. 45 No. 2 (225) (2011)

Section

Short Communications

License

Copyright (c) 2011 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.