ASYMMETRIC SYNTHESIS OF (R)-2-AMINO-3-(4-CYANO-1-MORPHO-LINO-5,6,7,8-TETRAHIDROISOQUINOLINE-3-YLTHIO)PROPIONIC ACID

Authors

  • A.V Geolchanyan Chair of Pharmaceutical Chemistry and Pharmacognosy, Institute of Pharmacy, Armenia

DOI:

https://doi.org/10.46991/PYSUB.2011.45.3.012

Keywords:

heterocyclic substituted propionic acid derivative, Ni(II) complex, Shiff`s base

Abstract

A method for asymmetric synthesis of new heterocyclic substituted propionic acid derivative via addition of 3-mercapto-1-morpholino-5,6,7,8-tetrahidroisoquinoline-4-carbonitrile to C=C bond of dehydroalanine moiety of Ni(II) complex its Shiff`s base with chiral auxiliary (S)-2-N-(N-benzylprolyl)aminobenzophenone was developed. After decomposition of deastereomeric mixture of complexes the target amino acid − (R)-2-amino-3-(4-cyano-1-morpholino-5,6,7,8-tetrahidroisoquinoline-3-ylthio)propionic acid, was isolated with ee > 98%.

Downloads

Published

2011-11-08

Issue

Vol. 45 No. 3 (226) (2011)

Section

Chemistry

License

Copyright (c) 2011 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“ASYMMETRIC SYNTHESIS OF (R)-2-AMINO-3-(4-CYANO-1-MORPHO-LINO-5,6,7,8-TETRAHIDROISOQUINOLINE-3-YLTHIO)PROPIONIC ACID”. 2011. Proceedings of the YSU B: Chemical and Biological Sciences 45 (3 (226): 12-15. https://doi.org/10.46991/PYSUB.2011.45.3.012.