THERMODYNAMICS OF INTERACTIONS OF CoTOEPyP4 PORPHYRIN WITH A-DNA

Authors

  • A.A. Avetisyan Chair of Molecular Physics, YSU, Armenia
  • Ye.B. Dalyan Chair of Molecular Physics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2014.48.3.040

Keywords:

DNA conformation, Co-porphyrin, alcohol solution, absorbance spectra, circular dichroism

Abstract

We have employed UV light absorption and circular dichroism methods to study the binding of water-soluble Co(II)-containing meso-tetra-(4N-oxyethylpyridyl) porphyrin (CoTOEPyP4) with B- and A-DNA from Calf Thymus. The binding constant Kb we determined from binding isotherms for each DNA–porphyrin complexes and calculated binding free energy ΔG, enthalpy ΔH and entropy ΔS. Our results suggest that CoTOEPyP4 porphyrin preferably binds via outside self-stacking mode with B- and A-DNA.

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Published

2014-11-14

How to Cite

Avetisyan, A.A., and Ye.B. Dalyan. 2014. “THERMODYNAMICS OF INTERACTIONS OF CoTOEPyP4 PORPHYRIN WITH A-DNA”. Proceedings of the YSU B: Chemical and Biological Sciences 48 (3 (235):40-45. https://doi.org/10.46991/PYSU:B/2014.48.3.040.

Issue

Vol. 48 No. 3 (235) (2014)

Section

Biology

License

Copyright (c) 2014 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.