SYNTHESIS, STRUCTURE AND BINDING AFFINITY OF A NOVEL 1,2,3-TRIAZOLYL-CARVONE WITH BOVINE SERUM ALBUMIN

Authors

  • K.R. Grigoryan Chair of Physical and Colloids Chemistry, YSU, Armenia
  • A.S. Galstyan Chair of Organic Chemistry, YSU, Armenia
  • M.A. Samvelyan Chair of Organic Chemistry, YSU, Armenia
  • T.V. Ghochikyan Chair of Organic Chemistry, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2018.52.3.155

Keywords:

1,2,3-triazolyl-carvone, antibacterial activity, fluorescence spectroscopy, binding parameters, albumin

Abstract

On the basis of natural L-carvone monoterpenoide, a method for the synthesis of (5R)-2-methyl-5-(3-{4-[(azepan-1-yl)methyl]-1H-1,2,3-triazol-1-yl}prop-1-en-2-yl)cyclohex-2-en-1-one has been developed. The reaction conditions providing high yields of the target products were optimized. The structure of the synthesized compound has been confirmed and the physicochemical constants have been determined. The nature of the interaction and the thermodynamic characteristics of the 1,2,3-triazolyl-carvone with serum albumin (BSA) have been also determined. It has been shown that hydrophobic interactions are the predominant intermolecular forces stabilizing 1,2,3-triazolyl-carvone–BSA system. The distance between donor (BSA) and acceptor (1,2,3-triazolyl-carvone) has been calculated using Förster’s fluorescence energy transfer theory.

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Published

2018-11-20

How to Cite

Grigoryan, K.R., A.S. Galstyan, M.A. Samvelyan, and T.V. Ghochikyan. 2018. “SYNTHESIS, STRUCTURE AND BINDING AFFINITY OF A NOVEL 1,2,3-TRIAZOLYL-CARVONE WITH BOVINE SERUM ALBUMIN”. Proceedings of the YSU B: Chemical and Biological Sciences 52 (3 (247):155-60. https://doi.org/10.46991/PYSU:B/2018.52.3.155.

Issue

Section

Chemistry

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