FLUORESCENCE STUDIES ON THE BLOOD PLASMA ALBUMIN INTERACTION WITH 4-HYDROXY-2-METHYLQUINOLINE

Authors

  • Karine R. Grigoryan Chemical Research Center, Laboratory of Physical Chemistry, YSU, Armenia
  • Hasmik A. Shilajyan Chemical Research Center, Laboratory of Physical Chemistry, YSU, Armenia
  • Iskuhi L. Aleksanyan Chemical Research Center, Laboratory of Organic Chemistry, YSU, Armenia
  • Lilit P. Hambardzumyan Chemical Research Center, Laboratory of Organic Chemistry, YSU, Armenia
  • Hasmik H. Hovhannisyan Chemical Research Center, Laboratory of Physical Chemistry, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2022.56.2.100

Keywords:

4-hydroxy-2-methylquinoline, bovine serum albumin, fluorescence spectroscopy, synchronous fluorescence, excitation / emission matrix

Abstract

Blood plasma albumin (bovine serum albumin, BSA) interaction with a biologically active reagent 4-hydroxy-2-methylquinoline (4H2MQ) has been studied using fluorescence spectroscopy methods (steady state, synchronous, excitation/emission matrix, 3D spectra). With the addition of 4H2MQ, no changes in the spectral characteristics of BSA (fluorescence emission intensity and λmax position) are observed; only the symmetry of the BSA emission spectrum is changed and the full width at half maximum is decreased. The analysis of synchronous and 3D fluorescence spectra showed the existence of three emitting species in this system, which could be a result of changes in the fluorescence and photochemical properties of 4H2MQ.

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Published

2022-06-30

How to Cite

Grigoryan, Karine R., Hasmik A. Shilajyan, Iskuhi L. Aleksanyan, Lilit P. Hambardzumyan, and Hasmik H. Hovhannisyan. 2022. “FLUORESCENCE STUDIES ON THE BLOOD PLASMA ALBUMIN INTERACTION WITH 4-HYDROXY-2-METHYLQUINOLINE”. Proceedings of the YSU B: Chemical and Biological Sciences 56 (2 (258):100-107. https://doi.org/10.46991/PYSU:B/2022.56.2.100.

Issue

Vol. 56 No. 2 (258) (2022)

Section

Chemistry

License

Copyright (c) 2022 Proceedings of the YSU

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