HYPOBARIC HYPOXIA CAUSING HISTOMORPHOLOGICAL ALTERATIONS IN DIFFERENT PARTS OF THE RAT'S BRAIN

Authors

  • Ruzanna A. Shushanyan Chair of Human and Animal Physiology, YSU, Armenia
  • Anna V. Grigoryan Chair of Human and Animal Physiology, YSU, Armenia
  • Anna F. Karapetyan Chair of Human and Animal Physiology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2022.56.3.266

Keywords:

neurodegeneration, hypobaric hypoxia, cortex, striatum, hippocampus, histomorphology

Abstract

Hypobaric hypoxia causes degenerative changes in different parts of the brain, which leads to the formation of cerebral edema. This study aimed to investigate the morphohistological changes in the brain of rats exposed to hypobaric hypoxia. In particular, the hippocampus, cerebral cortex, and striatum were studied. Animals were exposed to hypobaric hypoxia for 10 days. Histomorphological examination showed degenerative changes in the hippocampus, dentate gyrus, and striatum, accompanied by pyknosis of neuronal nuclei, cytoplasmic vacuolization, and neuronal shrinkage, while the cortex of the large hemispheres remained almost intact. Histological studies showed that different parts of the brain respond to hypoxic conditions with different manifestations.

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Published

2022-12-28

How to Cite

Shushanyan, Ruzanna A., Anna V. Grigoryan, and Anna F. Karapetyan. 2022. “HYPOBARIC HYPOXIA CAUSING HISTOMORPHOLOGICAL ALTERATIONS IN DIFFERENT PARTS OF THE RAT’S BRAIN”. Proceedings of the YSU B: Chemical and Biological Sciences 56 (3 (259):266-74. https://doi.org/10.46991/PYSU:B/2022.56.3.266.

Issue

Vol. 56 No. 3 (259) (2022)

Section

Biology

License

Copyright (c) 2022 Proceedings of the YSU

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