CELL-FREE MITOCHONDRIAL DNA IN DOXORUBICIN-TREATED KCL22 AND K562 CELL LINES
DOI:
https://doi.org/10.46991/PYSU:B.2024.58.1.009Keywords:
doxorubicin, cell-free mtDNA, PCR, gel electrophoresis, cytotoxicity, genotoxicity, KCL22 and K562 cellsAbstract
Cell-free mitochondrial DNA (cf-mtDNA) is widely used as a biomarker of pathological processes, but its application for assessing the effects of environmental factors is limited. For the first time, cf-mtDNA was identified in the KCL22 cell culture treated with doxorubicin, which is known for its ability to disrupt mitochondrial functions. The results obtained indicate the effectiveness of using cf-mtDNA as a biomarker of genotoxic and cytotoxic effects.
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Published
2024-04-24
How to Cite
Harutyunyan, Tigran A., Anzhela A. Sargsyan, Lily A. Kalashyan, Hovhannes A. Igityan, Rouben M. Aroutiounian, and Galina G. Hovhannisyan. 2024. “CELL-FREE MITOCHONDRIAL DNA IN DOXORUBICIN-TREATED KCL22 AND K562 CELL LINES”. Proceedings of the YSU B: Chemical and Biological Sciences 58 (1 (263):9-16. https://doi.org/10.46991/PYSU:B.2024.58.1.009.
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Biology
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