STEREOSELECTIVE SYNTHESIS OF S-TRET-BUTYL-D-CYSTEINE VIA A CHIRAL NI2+ COMPLEX OF DEHYDROALANINE
DOI:
https://doi.org/10.46991/PYSUB.2001.35.2.064Abstract
An efficient method of asymmetric stoichiometric synthesis of s-t-butyl-D-cysteine via addition of t-(CH3)CSH to the double C=C bond of dehydroalanine in its chiral Ni2+ complex of Schiffs base with the chiral auxiliary D-2-N-(N’-benzylprolyl)aminobenzophenone was elaborated. The optical active amino acid s-t-butyl-D-cysteine with high optical purity (e.e. > 98%) was separated after decomposition of the reaction mixture by HCl. The stereoselectivity of nucleophilic addition amounts 92%.
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2001-07-09
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Chemistry
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“STEREOSELECTIVE SYNTHESIS OF S-TRET-BUTYL-D-CYSTEINE VIA A CHIRAL NI2+ COMPLEX OF DEHYDROALANINE”. 2001. Proceedings of the YSU B: Chemical and Biological Sciences 35 (2 (195): 64-69. https://doi.org/10.46991/PYSUB.2001.35.2.064.
