ROLE OF HYDROPHOBIC INTERACTIONS AT THE THERMAL DENATURATION OF HUMAN AND BOVINE SERUM ALBUMINS AT THE PRESENCE OF DIALKYLSULFOXIDES

Authors

  • K. R. Grigoryan Chair of Physical and Colloids Chemistry, YSU, Armenia
  • A. A. Shilajyan Chair of Physical and Colloids Chemistry, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2009.43.3.003

Keywords:

dialkylsulfoxides, thermal denaturation, UV/vis absorption spectroscopy method, serum albumin

Abstract

The effect of dialkylsulfoxides (DASO) on the thermal denaturation of serum albumins human and bovine in the temperature range 20–90oC has been investigated by the UV/vis absorption spectroscopy method. It has been shown that in the homologous series of DASO hydrophobic interactions with proteins become more effective. However, with the elongation of hydrocarbon chain, starting from dipropylsulfoxide, in consequence of breaking the diffusion of sulfoxide molecules, denaturation of proteins is observed at higher temperatures.

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Published

2009-10-22

How to Cite

Grigoryan, K. R., and A. A. Shilajyan. 2009. “ROLE OF HYDROPHOBIC INTERACTIONS AT THE THERMAL DENATURATION OF HUMAN AND BOVINE SERUM ALBUMINS AT THE PRESENCE OF DIALKYLSULFOXIDES ”. Proceedings of the YSU B: Chemical and Biological Sciences 43 (3 (220):3-6. https://doi.org/10.46991/PYSU:B/2009.43.3.003.

Issue

Vol. 43 No. 3 (220) (2009)

Section

Chemistry

License

Copyright (c) 2009 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.