$In~vitro$ STUDY OF STRUCTURE/ACTIVITY DEPENDENCE OF NEW PORPHYRINES AS RADIOSENSITIZERS
DOI:
https://doi.org/10.46991/PYSU:B/2011.45.2.034Keywords:
porphyrine, radiosensitizing effect, cytotoxicity, anticancer activityAbstract
The aim of this work has been the investigation of structure/activity dependence of new porphyrines to improve their radiosensitizing effects. In this work it was shown that the cytotoxicity of water-soluble porphyrines depends on the type of central metal atom and ranges in the following order: ZnTOEt4PyP>MnTOEt4PyP>AgTOEt4PyP>FeTOEt4PyP>H2TOEt4PyP>CoTOEt4PyP>CuTOEt4PyP. Only AgTOEt4PyP and CuTOEt4PyP porphyrines demonstrated the radiosensitizing activity (DMF=1.9). Thus, the radiosensitizing activity of porphyrines depends on the structure, and structure modifications can be a way to improve their anticancer activity and pharmacological features.
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