$In~vitro$ STUDY OF STRUCTURE/ACTIVITY DEPENDENCE OF NEW PORPHYRINES AS RADIOSENSITIZERS

Authors

  • N.S. Babayan Chair of Genetics and Cytology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2011.45.2.034

Keywords:

porphyrine, radiosensitizing effect, cytotoxicity, anticancer activity

Abstract

The aim of this work has been the investigation of structure/activity dependence of new porphyrines to improve their radiosensitizing effects. In this work it was shown that the cytotoxicity of water-soluble porphyrines depends on the type of central metal atom and ranges in the following order: ZnTOEt4PyP>MnTOEt4PyP>AgTOEt4PyP>FeTOEt4PyP>H2TOEt4PyP>CoTOEt4PyP>CuTOEt4PyP. Only AgTOEt4PyP and CuTOEt4PyP porphyrines demonstrated the radiosensitizing activity (DMF=1.9). Thus, the radiosensitizing activity of porphyrines depends on the structure, and structure modifications can be a way to improve their anticancer activity and pharmacological features.

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Published

2011-05-11

How to Cite

Babayan, N.S. 2011. “$In~vitro$ STUDY OF STRUCTURE ACTIVITY DEPENDENCE OF NEW PORPHYRINES AS RADIOSENSITIZERS”. Proceedings of the YSU B: Chemical and Biological Sciences 45 (2 (225):34-38. https://doi.org/10.46991/PYSU:B/2011.45.2.034.

Issue

Vol. 45 No. 2 (225) (2011)

Section

Biology

License

Copyright (c) 2011 Proceedings of the YSU

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