CHEMOSELECTIVITY OF AMINOMETHYLATION OF AMINO- AND ALKOXYETHANOLS IN CHARGE UNITS OF GENERAL THEORY OF ACIDS AND BASES

Authors

  • K.H. Petrosyan Institute of Organic Chemistry of Scientific-Technological Center of Organic and Pharmaceutical Chemistry, NAS RA

DOI:

https://doi.org/10.46991/PYSUB.2016.50.3.060

Keywords:

chemoselectivity, aminomethylation, acid of Pauling, base of Pauling

Abstract

The evidence on the violation of chemoselectivity of aminomethylation of dimethyl- and diethylaminoethanol, which occurs under the influence of hydrogen bond was received. The same hydrogen bond occurs in the oxygen analogues of aminoethanols and β-alkoxietanols, but contrary to expectations, it is not accompanied by a change in the chemoselectivity of the reaction. We propose a rationale to explain the differences in the properties of these molecules, using charge units of the ionic character of the bond.

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Published

2016-11-21

Issue

Vol. 50 No. 3 (241) (2016)

Section

Short Communications

License

Copyright (c) 2016 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

“CHEMOSELECTIVITY OF AMINOMETHYLATION OF AMINO- AND ALKOXYETHANOLS IN CHARGE UNITS OF GENERAL THEORY OF ACIDS AND BASES”. 2016. Proceedings of the YSU B: Chemical and Biological Sciences 50 (3 (241): 60-63. https://doi.org/10.46991/PYSUB.2016.50.3.060.