SYNTHESIS AND STUDY OF THE NEMATOCIDAL ACTIVITY OF 1,2,4-TRIAZOLO-1,2,4-TRIAZOLES

Authors

  • M.A. Samvelyan Chair of Organic Chemistry, YSU, Armenia
  • T.V. Ghochikyan Chair of Organic Chemistry, YSU, Armenia
  • T.H. Yeganyan Chair of Organic Chemistry, YSU, Armenia
  • M. Sarfraz Chair of Pharmacy, Saarland University, Germany
  • C. Jakob Chair of Pharmacy, Saarland University, Germany

DOI:

https://doi.org/10.46991/PYSU:B/2020.54.1.003

Keywords:

1,2,4-triazoles, hydrazides, 1,2,4-triazolo-1,2,4-triazoles, nematodes, nematocidal activity

Abstract

The method has been developed for the preparation of ethyl esters of triazolo-substituted thioglycolic acid, basis on which the corresponding hydrazides, thiosemicarbazides and 1,2,4-triazolo-1,2,4-triazoles were synthesized by successive transformations. By the data of 1H and 13C NMR spectroscopy and elemental analysis have been established the structures of obtained compounds. Biological studies have shown that triazolo-triazoles at concentrations of 50 and 100 μm/mL reduce the viability of nematodes Steinernema Feltiae by 10–40%.

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Published

2020-04-15

How to Cite

Samvelyan, M.A., T.V. Ghochikyan, T.H. Yeganyan, M. Sarfraz, and C. Jakob. 2020. “SYNTHESIS AND STUDY OF THE NEMATOCIDAL ACTIVITY OF 1,2,4-TRIAZOLO-1,2,4-TRIAZOLES”. Proceedings of the YSU B: Chemical and Biological Sciences 54 (1 (251):3-11. https://doi.org/10.46991/PYSU:B/2020.54.1.003.

Issue

Vol. 54 No. 1 (251) (2020)

Section

Chemistry

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Copyright (c) 2020 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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