SYNTHESIS OF NEW 1,2,4-TRIAZOLE DERIVATIVES AND STUDY OF THEIR ANTINEMATODE ACTIVITY

Authors

  • A.S. Galstyan Chair of Organic Chemistry, YSU, Armenia
  • T.V. Ghochikyan Chair of Organic Chemistry, YSU, Armenia
  • V.R. Frangyan Chair of Organic Chemistry, YSU, Armenia
  • M. Sarfraz Chair of Pharmacy, Saarland University, Germany
  • C. Jacob Chair of Pharmacy, Saarland University, Germany

DOI:

https://doi.org/10.46991/PYSU:B/2019.53.3.147

Keywords:

1,2,4-triazoles, β-heterocyclic alanines, triazolo-triazoles, antinematode activity

Abstract

A method for obtaining methyl esters of β-1,2,4-triazole-substituted alanines by condensation of methyl acrylate with 3,4-disubstituted 5-mercapto-1,2,4-triazoles has been developed. Based on the products obtained, a number of new biheterocyclic systems, previously not described in the literature, have been synthesized. By testing the obtained compounds it was established that individual representatives of the latter exhibited antinematode activity for agricultural nematodes Steinernema feltiae, increasing the viability of the latter by 3–5%.

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Published

2019-12-18

How to Cite

Galstyan, A.S., T.V. Ghochikyan, V.R. Frangyan, M. Sarfraz, and C. Jacob. 2019. “SYNTHESIS OF NEW 1,2,4-TRIAZOLE DERIVATIVES AND STUDY OF THEIR ANTINEMATODE ACTIVITY”. Proceedings of the YSU B: Chemical and Biological Sciences 53 (3 (250):147-55. https://doi.org/10.46991/PYSU:B/2019.53.3.147.

Issue

Vol. 53 No. 3 (250) (2019)

Section

Chemistry

License

Copyright (c) 2019 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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