STUDY OF THE BIOLOGICAL PROPERTIES OF SEMI- AND THIOSEMICARBAZONES OF CARBONYL DERIVATIVES OF 4-BUTANOLIDES

Authors

  • Tariel V. Ghochikyan Chair of Organic Chemistry, YSU, Armenia
  • Armen S. Galstyan Chair of Organic Chemistry, YSU, Armenia
  • Hrachik M. Stepanyan Scientific Technological Center of Organic and Pharmaceutical Chemistry of NAS RA, Armenia
  • Irina G. Korpakova FSUE «Azov Fisheries Research Institute» (AzNIIRKH), Russian Federation
  • Alexander S. Kinzirsky Institute of Physiologically Active Compounds, Russian Academy of Sciences, Russian Federation

DOI:

https://doi.org/10.46991/PYSU:B/2021.55.2.103

Keywords:

4-butanolides, cyclic esters, algicidal activity, antitumor activity, antibacterial activity

Abstract

Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemi­carbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․

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Published

2021-08-30

How to Cite

Ghochikyan, Tariel V., Armen S. Galstyan, Hrachik M. Stepanyan, Irina G. Korpakova, and Alexander S. Kinzirsky. 2021. “STUDY OF THE BIOLOGICAL PROPERTIES OF SEMI- AND THIOSEMICARBAZONES OF CARBONYL DERIVATIVES OF 4-BUTANOLIDES”. Proceedings of the YSU B: Chemical and Biological Sciences 55 (2 (255):103-11. https://doi.org/10.46991/PYSU:B/2021.55.2.103.

Issue

Section

Chemistry