COMPARATIVE STUDY OF ETHIDIUM BROMIDE INTERACTION WITH SYNTHETIC POLYNUCLEOTIDES ds-POLY(rA)-POLY(rU) AND ds-POLY(dA)-POLY(dT)

Authors

  • M.A. Parsadanyan Chair of Biophysics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2019.53.3.175

Keywords:

DNA, synthetic polynucleotide, intercalator, complex, melting temperature

Abstract

A comparative study on the interaction of classical intercalator ethidium bromide (EtBr) with different nucleic acids (NA) has been carried out. EtBr was revealed to preferentially bind to ds-NA belonging to A-family, rather than to B-family, because the stabilizing effect of this ligand decreases in the following order: ds-poly(rA)-poly(rU), ds-poly(dA)-poly(dT), ds-DNA.

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Published

2019-12-18

How to Cite

Parsadanyan, M.A. 2019. “COMPARATIVE STUDY OF ETHIDIUM BROMIDE INTERACTION WITH SYNTHETIC POLYNUCLEOTIDES Ds-POLY(rA)-POLY(rU) AND Ds-POLY(dA)-POLY(dT)”. Proceedings of the YSU B: Chemical and Biological Sciences 53 (3 (250):175-79. https://doi.org/10.46991/PYSU:B/2019.53.3.175.

Issue

Vol. 53 No. 3 (250) (2019)

Section

Biology

License

Copyright (c) 2019 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.