EFFECTS OF Mg$^{2+}$, Cd$^{2+}$, Cu$^{2+}$ LOW CONCENTRATIONS AND IMMOBILIZATION STRESS ON THE ACTIVITY OF ADENOSINE DEAMINASE IN DIFFERENT ORGANS OF RABBITS

Abstract

Long-term restriction of motor activity is a factor that significantly complicates the processes of vital activity of the organism, accompanied by stress reaction and corresponding shifts in metabolism. The processes ensuring the change of immunity under stress depend on the activity of AMP-deaminase, 5'-nucleotidase, adenosine deaminase (ADA). Inosine, formed during deamination of adenosine activates the enzymes of lysis of necrotic masses, accelerates the maturation of connective tissue, increases the activity of antitumor and antioxidant enzymes. The result of the studies show, that with a 3 hour-immobilization of rabbits the activity of ADA in organs (liver, kidneys, brain) of animals decreases. Metal ions (Cd²⁺, Cu²⁺, Mg²⁺) also affect the activity of ADA in rabbits organs, even at a concentration of 1 μM ions, the activity of ADA is significantly reduced. The results obtained can be used to asses the immunological status of the organism.