THE INFLUENCE OF NON-PROTEIN AMINO ACIDS AND PEPTIDES ON BACTERIAL COLLAGENASE

Authors

  • Armen S. Sargsyan Scientific and Production Center "Armbiotechnology" NAS RA, Armenia
  • Ani J. Karapetyan Scientific and Production Center "Armbiotechnology" NAS RA, Armenia
  • Liana A. Hayriyan Scientific and Production Center "Armbiotechnology" NAS RA, Armenia
  • Anahit M. Hovhannisyan Chair of Pharmtechnology and Pharmacy Economics and Management, Institute of Pharmacy, YSU, Armenia
  • Marina A. Melkumyan Scientific and Production Center "Armbiotechnology" NAS RA, Armenia
  • Gohar G. Oganezova Scientific and Production Center "Armbiotechnology" NAS RA, Armenia
  • Nelli S. Avetisyan Scientific and Production Center "Armbiotechnology" NAS RA, Armenia
  • Nelli A. Hovhannisyan Scientific and Production Center "Armbiotechnology" NAS RA, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2022.56.2.126

Keywords:

non-protein amino acid, peptide, collagenase, inhibition

Abstract

Bacterial collagenolytic proteases have drawn increasing attention due to their essential role in the global nitrogen cycling and their virulent role in some diseases. The inhibition of these enzymes is attractive, as it does not attack the pathogen directly but rather blocks the colonization and infiltration of the host by the clostridia. Optically active non-protein α-amino acids have been screened for their ability to inhibit collagenase of Clostridium histolyticum. Both structure-based drug design approach (modeling) and that of determining enzyme activity in the presence of amino acids have been used to identify low molecular weight inhibitors of collagenase. The compounds able to inhibit collagenase activity have been revealed and IC50 values have been estimated.

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Published

2022-06-30

How to Cite

Sargsyan, Armen S., Ani J. Karapetyan, Liana A. Hayriyan, Anahit M. Hovhannisyan, Marina A. Melkumyan, Gohar G. Oganezova, Nelli S. Avetisyan, and Nelli A. Hovhannisyan. 2022. “THE INFLUENCE OF NON-PROTEIN AMINO ACIDS AND PEPTIDES ON BACTERIAL COLLAGENASE”. Proceedings of the YSU B: Chemical and Biological Sciences 56 (2 (258):126-30. https://doi.org/10.46991/PYSU:B/2022.56.2.126.

Issue

Section

Chemistry