CORRECTION BY ANTIOXIDANTS OF OXIDATIVE ACTIVITY IN AN EXPERIMENTAL MODEL OF PARKINSON'S DISEASE

Authors

  • Narine K. Hayrapetyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia https://orcid.org/0009-0006-1941-0378
  • Irina A. Badalyan Chair of Biochemistry, Microbiology and Biotechnology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2023.57.3.282

Keywords:

Parkinson's disease, oxidative stress, antioxidants, Lycium barbarum

Abstract

The advantage of the reserpine model in the development of parkinsonian syndrome in experimental animals was shown: symptoms appeared as early as 2 h after reserpine administration and persisted for up to 3 days. Injection of reserpine at a dose of 3 mg/kg, quite clearly influenced behaviour. Significant changes in biochemical indicators, markers of oxidative stress, accompanying disorders of motor functions of experimental animals were revealed. The possibility of correcting the pathology with the help of some agents of antioxidant nature has been shown. Despite the lack of clarity regarding the efficacy of succinate, tocopherol, the study showed that the use of goji berries significantly reduces the risk of Parkinson's disease.

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Published

2023-12-20

How to Cite

Hayrapetyan, Narine K., and Irina A. Badalyan. 2023. “CORRECTION BY ANTIOXIDANTS OF OXIDATIVE ACTIVITY IN AN EXPERIMENTAL MODEL OF PARKINSON’S DISEASE”. Proceedings of the YSU B: Chemical and Biological Sciences 57 (3 (262):282-91. https://doi.org/10.46991/PYSU:B/2023.57.3.282.

Issue

Vol. 57 No. 3 (262) (2023)

Section

Biology

License

Copyright (c) 2023 Proceedings of the YSU

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