SOME PECULIARITIES OF BINDING PODOPHYLLOTOXIN AND ETOPOSIDE WITH DNA OF DIFFERENT GC-CONTENT

Authors

  • H.R. Vardapetyan Chair of Biophysics, YSU, Armenia
  • A.S. Ryazanova Chair of Biophysics, YSU, Armenia
  • A.P. Antonyan Chair of Biophysics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2011.45.2.029

Keywords:

guanine-cytosine content, method of thermal denaturation, podophyllotoxin, etoposide, DNA

Abstract

Investigation of binding podophyllotoxin and etoposide with DNA of different guanine-cytosine content has been carried out using the method of thermal denaturation. It has been revealed, that podophyllotoxin and etoposide have a destabilizing effect on DNA. It has been shown that both compounds are preferably bound to AT-rich sites of DNA.

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Published

2011-05-11

How to Cite

Vardapetyan, H.R., A.S. Ryazanova, and A.P. Antonyan. 2011. “SOME PECULIARITIES OF BINDING PODOPHYLLOTOXIN AND ETOPOSIDE WITH DNA OF DIFFERENT GC-CONTENT”. Proceedings of the YSU B: Chemical and Biological Sciences 45 (2 (225):29-33. https://doi.org/10.46991/PYSU:B/2011.45.2.029.

Issue

Vol. 45 No. 2 (225) (2011)

Section

Biology

License

Copyright (c) 2011 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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