QUENCHING MECHANISM OF HUMAN SERUM ALBUMIN FLUORESCENCE BY GANGLERON

Authors

  • K.R. Grigoryan Chair of Physical and Colloids Chemistry, YSU, Armenia
  • A.G. Ghazaryan Chair of Physical and Colloids Chemistry, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2013.47.2.006

Keywords:

human serum albumin, Gangleron, fluorescence spectroscopy, UV/vis spectroscopy, dynamic quenching

Abstract

Interaction between Gangleron (spasmolytic and anaesthetizing drug) and human serum albumin (HSA) was studied using UV/vis and fluorescence spectroscopy methods. The quenching mechanism of HSA fluorescence was discussed based on interaction studies carried out at different temperatures (298, 303 and 309 K). Stern-Volmer constant (KSV), quenching rate constant (kq) and activation energy of bimolecular quenching (Еа) were evaluated. UV/vis absorption spectra were used to confirm the quenching mechanism. 

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Published

2013-07-08

How to Cite

Grigoryan, K.R., and A.G. Ghazaryan. 2013. “QUENCHING MECHANISM OF HUMAN SERUM ALBUMIN FLUORESCENCE BY GANGLERON”. Proceedings of the YSU B: Chemical and Biological Sciences 47 (2 (231):6-10. https://doi.org/10.46991/PYSU:B/2013.47.2.006.

Issue

Vol. 47 No. 2 (231) (2013)

Section

Chemistry

License

Copyright (c) 2013 Proceedings of the YSU

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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