THE INFLUENCE OF ANTITUMOR DRUG CIS-DDP ON PHYSICOCHEMICAL PROPERTIES OF DNA

Authors

  • Sh. A. Sargsyan Chair of Biophysics, YSU, Armenia
  • A. P. Antonyan Chair of Biophysics, YSU, Armenia
  • P. O. Vardevanyan Chair of Biophysics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2008.42.3.118

Keywords:

structural peculiarities of DNA, complexformation, ionization of nitrogen bases, chelates

Abstract

By the methods of UV spectroscopy and theoretical conformational analyses was investigated the structural peculiarities of DNA at complexformation with cis-DDP at extremal pH medium (pH< 4, pH>9). It was shown that by ionization of nitrogen bases, significant changes in Tm(pH) and ΔT(pH) take place. However, DNA-cis-DDP bidental interstand crosslink model and formation of chelates does not play а prior role at the platination.

Downloads

Published

2023-10-11

How to Cite

Sargsyan, Sh. A., A. P. Antonyan, and P. O. Vardevanyan. 2023. “THE INFLUENCE OF ANTITUMOR DRUG CIS-DDP ON PHYSICOCHEMICAL PROPERTIES OF DNA”. Proceedings of the YSU B: Chemical and Biological Sciences 42 (3 (217):118-24. https://doi.org/10.46991/PYSU:B/2008.42.3.118.

Issue

Vol. 42 No. 3 (217) (2008)

Section

Biology

License

Copyright (c) 2023 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.